Friday, April 16, 2021

Fact Check

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Must read

“There is racism physically built into some of our highways.”

The Overtown neighborhood in Miami, Fla. (Pietro, Creative Commons)Source link

NOT REAL NEWS: A look at what didn’t happen this week

A roundup of some of the most popular but completely untrue stories and visuals of the week. None of these are legit, even though...

Democrats agonize over game theory on Biden’s $2T-plus spending plan

But as much as Republicans trust Coons is acting in good faith, his idea doesn’t address the divisive political question of how to pay...

New this Week: ‘Kung Fu,’ ‘Rebel’ and ‘Thunder Force’

New this Week: ‘Kung Fu,’ ‘Rebel’ and ‘Thunder Force’ Source link

A gene therapy for hemophilia aims to restore a protein called factor that stabilizes fibrin (yellow), a component of blood clots.

DENNIS KUNKEL MICROSCOPY/Science Source

The company uniQure has concluded that a virus used widely in gene therapy was very unlikely to have caused liver cancer in a hemophilia patient in a clinical trial.

The tumor, detected in December 2020, raised concerns that the adeno-associated virus (AAV) used to carry a loop of DNA into the patient’s liver cells had inadvertently switched on a cancer gene. But uniQure’s tests of the patient’s tumor cells showed the AAV inserted into the genome in only a tiny fraction (0.027%) of the cells, and when it did, it landed in randomly scattered spots. If the AAV had triggered a single cell to grow out of control, the viral DNA would have shown up in the same spots in lots of the tumor cells.

The patient also had several known cancer mutations in his tumor cells, as well as risk factors for liver cancer including long-term hepatitis B and C infections.

The findings “support the conclusion that an AAV integration event was not likely responsible” for the liver tumor, says hemophilia gene therapy researcher Denise Sabatino of the Children’s Hospital of Philadelphia. “This is good news for the field.”

UniQure’s announcement today comes less than 3 weeks after another company, bluebird bio, found that a different virus called a lentiviral vector probably did not play a role in a patient’s leukemia in a gene therapy trial for sickle cell disease. Both companies are now hoping the U.S. Food and Drug Administration will lift holds on their trials.

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Latest article

“There is racism physically built into some of our highways.”

The Overtown neighborhood in Miami, Fla. (Pietro, Creative Commons)Source link

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A roundup of some of the most popular but completely untrue stories and visuals of the week. None of these are legit, even though...

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